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Intra-Brain Distribution After crossing the BBB via specific transporter, a drug, prodrug or nanocarrier can distribute from the brain ISF into the brain parenchymal cells via the same transporter expressed at the cellular membrane followed by the release of parent drug (in case of prodrugs and nanocarriers) or binding to the cell constituents, e.g

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( Reference Hultman, Soderlund and Timmons 22 ) adapted protocol with an overload supplementation period led to significant increases in plasma (154 %) and total intramuscular creatine (18 %) concentrations for the CrO+D group in relation to the control group

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